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| |
Appropriate EAMT (n = 41)
|
Inappropriate EAMT (n = 38)
|
p
|
Logistic regression results
|
|---|
|
OR
|
95% CI
|
p
|
|---|
|
Age, years (mean ± SD)
|
50 ± 18
|
55 ± 16
|
0.18
| | | |
|
Age > 50 years, n (%)
|
22 (53%)
|
26 (68%)
|
0.2
|
2.4
|
[0.67–8.51]
|
0.17
|
|
Sex-ratio
|
26/15
|
21/17
|
0.49
| | | |
|
SAPS II
|
36 ± 14
|
40 ± 16
|
0.26
| | | |
|
SOFA
|
5.2 ± 2.9
|
6.5 ± 3.7
|
0.076
| | | |
|
SOFA > 5, n (%)
|
14 (34%)
|
20 (52%)
|
0.13
|
1.66
|
[0.54–5.06]
|
0.36
|
|
Origin of NI acquisition
|
|
Medical ICU
|
9 (22%)
|
14 (37%)
|
0.18
|
0.61
|
[0.10–3.64]
|
0.6
|
|
ED*
|
22 (53%)
|
15 (39%)
|
0.20
|
1.14
|
[0.30–4.33]
|
0.84
|
|
Medical department
|
5 (12%)
|
8 (21%)
|
0.32
| | | |
|
Other
|
5 (12%)
|
1 (2.6)
|
–
| | | |
|
Co-morbidities
| | | | | | |
|
Diabetes
|
17 (41%)
|
14 (37%)
|
0.36
|
0.26
|
[0.075–0.93]
|
0.038
|
|
Chronic respiratory failure
|
19 (46%)
|
8 (21%)
|
0.032
|
1.42
|
[0.43–4.67]
|
0.56
|
|
Immunosuppression/neoplasia
|
7 (17%)
|
6 (16%)
|
0.99
| | | |
|
Cardiovascular disease
|
17 (41%)
|
24 (63%)
|
0.079
| | | |
|
Nature of suspected NI:
|
|
VAP
|
33 (80%)
|
26 (68%)
|
0.2
|
0.6
|
[0.19–1.94]
|
0.40
|
|
Bloodstream infection
|
6 (15%)
|
6 (16%)
|
–
| | | |
|
CRI
|
2 (5%)
|
5 (13%)
|
–
| | | |
|
UI
|
0
|
1 (2.6%)
|
–
| | | |
|
LOS pre-NI acquisition, days (med [IQR])
|
5 [3–10]
|
8 [6–14]
|
0.09
| | | |
|
LOS pre-NI > 6 days
|
10 (24%)
|
20 (52%)
|
0.012
|
4.44
|
[1.06–20.4]
|
0.05
|
|
Prior antimicrobials
|
32 (78%)
|
32 (84%)
|
0.57
| | | |
|
Pre-exposure to imipenem
|
10 (24%)
|
11 (29%)
|
0.8
| | | |
|
Pre-exposure to beta-lactams (other than imipenem)
|
20 (49%)
|
18 (47%)
|
0.82
| | | |
|
Pre-exposure to colistin
|
7 (17%)
|
8 (21%)
|
0.77
| | | |
|
Pre-exposure to glycopeptides
|
7 (17%)
|
4 (10.5%)
|
0.52
| | | |
|
Recent surgery
|
4 (10%)
|
10 (26.5%)
|
0.061
|
1.69
|
[0.37–7.66]
|
0.49
|
|
Shock
|
16 (39%)
|
16 (42%)
|
0.82
| | | |
|
Mechanical ventilation
|
40 (97.5%)
|
37 (97.3%)
|
1
| | | |
|
Tracheostomy
|
17 (41%)
|
16 (42%)
|
0.81
| | | |
|
Current corticosteroid
|
5 (12%)
|
5 (13%)
|
1
| | | |
- EAMT, empiric antimicrobial therapy; SD, standard derivation; SAPS, Simplified Acute Physiology Score Evaluation; SOFA, Sequential Organ Failure Assessment; ICU, intensive care unit; ED, emergency department; NI, nosocomial infection; VAP, ventilator acquired pneumonia; CRI, catheter related infection; UI, urinary infection; LOS, length of stay; IQR, interquartile range; OR, odds ratio; CI, confidence interval
- Italic values indicate p < 0.05
