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Table 2 Microbiological data in study groups

From: Appropriateness of empiric antimicrobial therapy with imipenem/colistin in severe septic patients: observational cohort study

Subgroups Appropriate EAMT group (n = 41) Inappropriate EAMT group (n = 38)
Enlargement (n = 22) Change (n = 9) De-escalation (n = 7)
Bacteriologic documentation, n 28/41 18/22 9/9 7/7
NI location
 VAP 22 11 2 4
 Bacteraemia 3 7 3 2
 CRI 2 5 3 0
 CRB 1 1 0 1
 UI 0 1 1 0
Isolates (n)
 Acinetobacter B 14 6 0 0
 Klebsiella pneumonia 6 4 0 0
 Pseudomonas spp. 5 5 3 5
 Enterobacter 2 4 1 0
 E. coli 0 1 0 0
 Staphylococcus 0 4 1 0
 Enterococcus 0 3 1 0
 Stenotrophomonas M 0 3 2 0
 Burkholderiacepacia 1 0 0 0
 Streptocoque spp. 0 0 0 2
 Candida species 0 7 1 0
Antimicrobial adjustment Imipenem/colistin Imipenem/colistin/Glycopeptid (n = 8) Other betalactam (for resistance to impenem)  + tygecycline, aminoglycoside or quinolone (n = 6) Piperacilline (n = 2)
Imipenem/colistin/antifungal (n = 7) Glycopeptide ± aminoside (n = 2) Ceftazidime (n = 3)
Imipenem/colistin/Tygecycline/aminglyosides (n = 3) Antifungal (n = 1) Cefotaxime (n = 2)
  1. EAMT, empiric antimicrobial therapy; NI, nosocomial infection; VAP, ventilator acquired pneumonia; CRI, catheter related infection; CRB, catheter related bacteraemia; UI, urinary infection